Chloroquine and hydroxychloroquine are decades-old malaria drugs French doctors tested on coronavirus patients. Six patients in the tiny study of about 20 happened to also be on azithromycin for other conditions while also being administered the malaria drugs. The initial COVID-19 data about azithromycin came from simply a few patients in an observational “open label” study, which makes it difficult to isolate variables and say whether a particular drug is working.
Through the 2015-2016 ZIKV epidemic, there were an incredible number of cases of ZIKV infection and about 3,000 confirmed cases of ZIKV congenital syndrome . Despite this, there are no approved vaccines or drugs to combat ZIKV infection or even to treat its neurological sequelae. Consequently, there can be an urgent dependence on anti-ZIKV therapeutics. Azithromycin is a trusted antibiotic, with additional antiviral and anti-inflammatory properties that remain poorly understood. Although Zika virus poses a substantial threat to global health, there are no vaccines or effective therapeutics against it.
Azithromycin inhibits protein synthesis in bacterial cells by binding to the 50S subunit of bacterial ribosomes. Action is normally bacteriostatic but can be bactericidal in high concentrations or against susceptible organisms. Azithromycin is more active against gram-negative organisms but has less activity against streptococci and staphylococci than does erythromycin; erythromycin-resistant gram-positive isolates demonstrate cross-resistance to azithromycin. Azithromycin concentrates in phagocytes and fibroblasts resulting in high intracellular concentrations. Drug distribution to inflamed tissues is considered to occur from the concentration in phagocytes.
Because of this, the drug may cause side effects in a kid who’s breastfed. These side effects can include diarrhea, vomiting, and rash. Taking this blood thinner drug with azithromycin may increase your threat of bleeding. Your physician will monitor you closely if you take these drugs together. If you curently have liver disease, it might worsen your liver function.
Chlamydia can cause symptoms such as sore throat and swollen glands. It can also cause fever, loss of appetite, and white spots on your tonsils. Verywell Health uses only high-quality sources, including peer-reviewed studies, to aid the facts within our articles. Read our editorial process for more information about how precisely we fact-check and keep our content accurate, reliable, and trustworthy. Check your prescription and speak to your doctor to ensure you are taking the right dose for you.